Elwan Nagwa Mohammad, Gheida Shereen Farouk, Hawwam Soha Abdalla, Ahmed Abeer Hussien
a Dermatology and Venereology Department, Faculty of Medicine , Tanta University Hospitals Egypt , Tanta , Egypt.
b Department of Dermatology , Kafr Elzayat General Hospital in Gharbia Egypt , Tanta , Egypt.
J Dermatolog Treat. 2018 Dec;29(8):786-791. doi: 10.1080/09546634.2018.1466025. Epub 2018 May 7.
Psoriasis is one of the most prevalent immune mediated skin diseases. Selective vascular destruction by pulsed dye laser is considered one of effective laser treatments.
Evaluation of the therapeutic effect of pulsed dye laser in treatment of chronic psoriatic plaque lesions and changes in human beta defensin-2(HBD-2) expression in the psoriatic patients before and after treatment, with correlation to the clinical improvement.
Twenty patients with psoriatic plaque on right side treated by laser and another plaque on left side similar in size and its severity score served as control receiving no treatment. Each patient received 3-4 sessions of pulsed dye laser 595 nm. Follow up was done for three months.
There was statistically significant difference between the two psoriatic plaques (untreated and treated; A and B; p = .004). There was significant decrease in HBD-2 expression after treatment. No recurrence was observed during follow up period.
The pulsed dye laser is safe, effective, and tolerable treatment for resistant stable localized plaque psoriasis with minimal side effects and prolonged recurrence period.
银屑病是最常见的免疫介导性皮肤病之一。脉冲染料激光选择性血管破坏被认为是有效的激光治疗方法之一。
评估脉冲染料激光治疗慢性银屑病斑块状皮损的疗效，以及银屑病患者治疗前后人β-防御素-2（HBD-2）表达的变化，并与临床改善情况相关联。
20例右侧有银屑病斑块的患者接受激光治疗，左侧大小和严重程度评分相似的另一斑块作为对照，不接受治疗。每位患者接受3 - 4次595nm脉冲染料激光治疗。随访3个月。
两块银屑病斑块（未治疗和治疗后；A和B）之间存在统计学显著差异（p = 0.004）。治疗后HBD-2表达显著降低。随访期间未观察到复发。
脉冲染料激光是治疗顽固性稳定局限性斑块状银屑病的安全、有效且耐受性良好的治疗方法，副作用最小且复发期延长。
