脉冲染料激光治疗甲银屑病。
Pulsed dye laser in the treatment of nail psoriasis.
机构信息
Dermatology Unit, American Hospital, Istanbul, Turkey.
出版信息
Dermatol Surg. 2010 Mar;36(3):377-81. doi: 10.1111/j.1524-4725.2009.01448.x. Epub 2010 Jan 19.
BACKGROUND
The treatment options for nail psoriasis have been limited, and the management of nail psoriasis has been challenging for physicians.
OBJECTIVES
To evaluate the effect of pulsed dye laser (PDL) in the treatment of nail psoriasis.
METHODS
Psoriatic nails of five patients were treated using PDL (595 nm) once monthly for 3 months. The pulse duration was 1.5 ms, the beam diameter was 7 mm, and the laser energy was 8.0 to 10.0 J/cm(2). Clinical efficacy was statistically evaluated according to Nail Psoriasis Severity Index (NAPSI) score differences before and after the treatment.
RESULTS
Statistical analysis of NAPSI scores before and after treatment showed significant difference (p<.05, paired t-test). The nail bed lesions, particularly onycholysis and subungual hyperkeratosis, responded best to the treatment.
LIMITATIONS
Limitations include the lack of blinding and comparison and the small number of patients.
CONCLUSION
PDL might be an alternative treatment for nail psoriasis. The authors have indicated no significant interest with commercial supporters.
背景
指甲银屑病的治疗选择有限，且指甲银屑病的治疗一直是医生面临的挑战。
目的
评估脉冲染料激光（PDL）治疗指甲银屑病的疗效。
方法
对 5 例银屑病指甲患者，采用 595nmPDL 治疗，每月 1 次，共 3 个月。脉冲持续时间 1.5ms，光斑直径 7mm，激光能量 8.0-10.0J/cm(2)。根据治疗前后 Nail Psoriasis Severity Index（NAPSI）评分的差异，对临床疗效进行统计学评估。
结果
治疗前后 NAPSI 评分的统计学分析显示差异有统计学意义（p<.05，配对 t 检验）。甲板病变，尤其是甲分离和甲下过度角化，对治疗反应最佳。
局限性
局限性包括缺乏盲法和对照以及患者数量少。
结论
PDL 可能是治疗指甲银屑病的一种替代方法。作者表示与商业支持者没有重大利益关系。
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