Wollmer M Axel, Neumann Insa, Magid Michelle, Kruger Tillmann H
Asklepios Clinic North-Ochsenzoll, Asklepios Campus Hamburg, Faculty of Medicine, Semmelweis University of Budapest, Hamburg, Germany -
Asklepios Clinic North-Ochsenzoll, Asklepios Campus Hamburg, Faculty of Medicine, Semmelweis University of Budapest, Hamburg, Germany.
G Ital Dermatol Venereol. 2018 Aug;153(4):540-548. doi: 10.23736/S0392-0488.18.05987-4. Epub 2018 Apr 18.
Treating glabellar frown lines with injections of botulinum toxin is the most frequently applied procedure in aesthetic medicine. In addition to its cosmetic effect, botulinum toxin may also positively modulate mood and affect, which may contribute to its popularity. A series of clinical studies has shown that this modulation can be used in the treatment of major depression. After a single glabellar treatment with botulinum toxin, patients suffering from unipolar depression experienced a quick, strong and sustained improvement in the symptoms of depression. Preliminary data suggest that botulinum toxin therapy may also be effective in the treatment of other mental disorders characterized by an excess of negative emotions, such as borderline personality disorder. Thus, the extreme bottom-up approach of paralyzing the facial muscles to influence the emotional brain via proprioceptive feedback mechanisms may represent a paradigm shift in psychiatric therapy.
在美容医学中，注射肉毒杆菌毒素治疗眉间皱纹是最常用的方法。除了其美容效果外，肉毒杆菌毒素还可能对情绪和情感产生积极调节作用，这可能是其广受欢迎的原因之一。一系列临床研究表明，这种调节作用可用于治疗重度抑郁症。在用肉毒杆菌毒素单次治疗眉间后，患有单相抑郁症的患者抑郁症状迅速、显著且持续改善。初步数据表明，肉毒杆菌毒素疗法可能对治疗其他以负面情绪过多为特征的精神障碍也有效，如边缘型人格障碍。因此，通过本体感觉反馈机制麻痹面部肌肉以影响情感大脑的极端自下而上方法可能代表了精神治疗的范式转变。
