Kruger Tillmann H C, Wollmer M Axel
Department of Psychiatry, Social Psychiatry and Psychotherapy, Medical School Hannover, Germany.
Asklepios Clinic North - Ochsenzoll, Asklepios Campus Hamburg, Medical Faculty, Semmelweis University, Germany.
Toxicon. 2015 Dec 1;107(Pt A):154-7. doi: 10.1016/j.toxicon.2015.09.035. Epub 2015 Sep 26.
The treatment of glabellar frown lines with botulinum toxin injection is one of the most prevalent procedures in esthetic medicine. It is possible that the popularity of this intervention is not only owing to its cosmetic effect but also to modulatory effects on mood and affectivity. Recently, a series of studies including three randomized controlled trials have consistently shown that such effects can be used in the treatment of depression. Predominantly female patients suffering from partly chronic and treatment resistant unipolar depression experienced a quick, strong and sustained improvement in depressive symptoms after a single glabellar treatment with botulinum toxin A as a sole or adjunctive therapy. If these findings are further corroborated in additional studies, the ever-growing spectrum of applications for botulinum toxin may spread into the field of psychiatry, showing that the superficial paralysis of facial muscles may, probably via proprioceptive feedback mechanisms, have profound effects on the emotional brain.
使用肉毒杆菌毒素注射治疗眉间皱纹是美容医学中最常见的手术之一。这种干预措施广受欢迎，可能不仅是因为其美容效果，还因为对情绪和情感有调节作用。最近，一系列研究（包括三项随机对照试验）一致表明，这种效果可用于治疗抑郁症。患有部分慢性和难治性单相抑郁症的主要为女性患者，在单次眉间注射肉毒杆菌毒素A作为单一或辅助治疗后，抑郁症状迅速、显著且持续改善。如果这些发现在更多研究中得到进一步证实，肉毒杆菌毒素不断扩大的应用范围可能会扩展到精神病学领域，这表明面部肌肉的表面麻痹可能通过本体感觉反馈机制，对情感大脑产生深远影响。
