Sharma Brij, Marwah Rishab, Raina Sujeet, Sharma Neetu, Kaushik Madan, Kaushal Satinder Singh
Trop Gastroenterol. 2016 Jan-Mar;37(1):37-41. doi: 10.7869/tg.317.
Cirrhosis of the liver is an important cause of morbidity and mortality in India. Currently no study exists on the disease from Himachal Pradesh, India. The purpose of this study was to evaluate epidemiological data on the etiological profile of cirrhosis of the liver in adults in a tertiary care hospital in a northern hilly state of Western Himalayas.
A hospital based, cross sectional, observational study was conducted in the department of Medicine and Gastroenterology in a tertiary care centre of Himachal Pradesh, located in northern India from 1st June, 2012 to 31st May, 2013. In total, 178 patients who were diagnosed with cirrhosis on the basis of history, physical examination, biochemistry and radiology, and of age >18 years were included in the study. Detailed history, examination and investigations were carried out in each case as per protocol.
Alcohol was the leading cause of cirrhosis in our study (62.9%), hepatitis B was the second(10.1%), Non-Alcoholic Steatohepatitis (NASH) was the third (7.9%), and autoimmune the fourth (3.9%) most common cause for cirrhosis. Hepatitis C was present in 2.8% of patients as a cause of cirrhosis. Wilson disease and cardiac cirrhosis were present in one patient each. In 9.6% the etiology was cryptogenic.
The study identified alcohol as the leading cause of cirrhosis among people in the state. Measures for taking care of preventable risk factors are desired.
在印度，肝硬化是发病和死亡的重要原因。目前尚无来自印度喜马偕尔邦关于该疾病的研究。本研究的目的是评估西喜马拉雅山脉北部一个丘陵邦的一家三级护理医院中成年肝硬化患者病因学特征的流行病学数据。
于2012年6月1日至2013年5月31日在印度北部喜马偕尔邦一家三级护理中心的内科和胃肠病科进行了一项基于医院的横断面观察性研究。共有178例基于病史、体格检查、生化检查和影像学检查被诊断为肝硬化且年龄大于18岁的患者纳入本研究。按照方案对每个病例进行了详细的病史、检查和调查。
在我们的研究中，酒精是肝硬化的主要病因（62.9%），乙型肝炎是第二大病因（10.1%），非酒精性脂肪性肝炎（NASH）是第三大病因（7.9%），自身免疫性疾病是第四大常见病因（3.9%）。2.8%的患者因丙型肝炎导致肝硬化。威尔逊病和心源性肝硬化各有1例患者。9.6%的病例病因不明。
该研究确定酒精是该邦人群肝硬化的主要病因。需要采取措施处理可预防的危险因素。
