Mishra Debakanta, Dash Kaibalya R, Khatua Chittaranjan, Panigrahi Subhendu, Parida Prasanta K, Behera Sambit K, Barik Rakesh K, Pradhan Subhasis, Sahu Saroj K, Thakur Bhaskar, Singh Shivaram P
Department of Gastroenterology, Institute of Medical Sciences and Sum Hospital, Bhubaneswar, Odisha, India.
Department of Gastroenterology, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, Odisha, India.
Euroasian J Hepatogastroenterol. 2020 Jan-Jun;10(1):1-6. doi: 10.5005/jp-journals-10018-1312.
The etiology of cirrhosis of liver is known to change with time due to various factors including awareness, preventive interventions, and lifestyle changes in society. However, there is scarce Indian data available about temporal trends in etiology of cirrhosis of liver. Hence, the aim of this study was to study the temporal trends in the etiology of cirrhosis of liver.
This is a retrospective study conducted in the Department of Gastroenterology, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, from January 2005 to December 2017. Data were collected from hospital records of all patients admitted to the Gastroenterology unit. A Poisson regression model was used to compare the hospitalization rate for different etiologies of cirrhosis of liver. All data were analyzed using Stata version 5.1 software.
A total of 4,331 hospitalized patients of cirrhosis of liver were included in the analysis, of whom 2,742 (63.3%) had alcohol-related cirrhosis, 858 (19.8%) had viral hepatitis-related cirrhosis, and 731 (16.9%) had cirrhosis of liver due to nonalcohol and nonviral causes. The proportion of alcohol-related cirrhosis was increased by 26% from 2005 to 2017 (RR 1.26, for trend <0.001). Though there were minimal ups and downs observed in the admission rate of viral hepatitis-related liver cirrhosis during later years, this was remarkably reduced by 73% (RR 0.27, for trend <0.001) in the year 2017 at the end of the study. Similarly, the proportion of cirrhosis due to nonalcohol and nonviral causes decreased by 26% (RR 0.74, for trend <0.001) by 2017.
Alcohol is the most common cause of cirrhosis of liver and the burden of alcohol-related cirrhosis is significantly increasing in comparison to other causes including viral infection, nonalcoholic steatohepatitis (NASH), and autoimmune hepatitis.
Mishra D, Dash KR, Khatua C, A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha. Euroasian J Hepato-Gastroenterol 2020;10(1):1-6.
由于包括认知、预防干预及社会生活方式改变等多种因素，已知肝硬化的病因会随时间而变化。然而，关于印度肝硬化病因的时间趋势，现有数据稀缺。因此，本研究旨在探讨肝硬化病因的时间趋势。
这是一项回顾性研究，于2005年1月至2017年12月在科塔克市的斯里拉玛·钱德拉·巴尼亚医学院及医院胃肠病科开展。数据收集自胃肠病科所有住院患者的医院记录。采用泊松回归模型比较不同病因肝硬化的住院率。所有数据使用Stata 5.1软件进行分析。
共有4331例肝硬化住院患者纳入分析，其中2742例（63.3%）为酒精性肝硬化，858例（19.8%）为病毒性肝炎相关性肝硬化，731例（16.9%）为非酒精及非病毒原因导致的肝硬化。2005年至2017年，酒精性肝硬化的比例增加了26%（相对危险度1.26，趋势P<0.001）。尽管在研究后期病毒性肝炎相关性肝硬化的入院率有微小波动，但在2017年研究结束时显著下降了73%（相对危险度0.27，趋势P<0.001）。同样，到2017年，非酒精及非病毒原因导致的肝硬化比例下降了26%（相对危险度0.74，趋势P<0.001）。
酒精是肝硬化最常见的病因，与包括病毒感染、非酒精性脂肪性肝炎（NASH）及自身免疫性肝炎等其他病因相比，酒精性肝硬化的负担显著增加。
米什拉D、达什KR、哈图阿C，《东奥里萨沿海地区肝硬化病因的时间趋势研究》。《欧亚肝脏胃肠病学杂志》2020年；10(1):1 - 6。
