Kandilarov Ilin K, Zlatanova Hristina I, Georgieva-Kotetarova Maria T, Kostadinova Ivanka I, Katsarova Mariana N, Dimitrova Stela Z, Lukanov Ludmil K, Sadakov Ferit
Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.
Department of Chemistry and Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria.
Folia Med (Plovdiv). 2018 Mar 1;60(1):110-116. doi: 10.1515/folmed-2017-0073.
Chronic stress is one of the main factors which lead to depression - a psychiatric disorder affecting millions of people and predicted to be the second ranked cause of premature death in 2020. Depression is often associated with cognitive disturbances and memory deficit. Plant based therapy could be effective in the treatment of mild to moderate depression due to its low level of adverse reaction, its good tolerability and compliance.
72 male Wistar rats, divided in 9 groups were given orally for 8 weeks two combinations of dry plant extracts - Antistress I and Antistress II and five individual dry extracts obtained from Serratula coronata, Hypericum perforatum, Valeriana officinalis, Crataegus monogyna and Melissa officinalis. The animals were exposed to a chronic unpredictable mild stress for 8 weeks. The depression-like symptoms were evaluated with Forced swim test while the assessment of the memory deficit was performed with Novel object recognition test.
Antistress II demonstrates antidepressant effect while Antistress I doesn't improve the depressive-like symptoms. The individual extracts of Hypericum perforatum and Valeriana officinalis also possess antidepressant properties. Antistress II improves the cognition as well as the individual extracts of Hypericum perforatum, Valeriana officinalis and especially Serratula coronata. Dry extract from Serratula tend to have the best effect regarding the recognition memory. The effect of Antistress I on memory deficit is negligible.
Antistress II possesses antidepressant effect and improves the recognition memory while Antistress I doesn't demonstrate any of the above-described effects.
慢性应激是导致抑郁症的主要因素之一。抑郁症是一种影响数百万人的精神疾病，预计在2020年将成为过早死亡的第二大原因。抑郁症常伴有认知障碍和记忆缺陷。植物疗法因其不良反应少、耐受性好和依从性高，可能对轻至中度抑郁症有效。
将72只雄性Wistar大鼠分为9组，连续8周口服两种干植物提取物组合——抗应激I和抗应激II，以及从麻花头、贯叶连翘、缬草、山楂和蜜蜂花中提取的五种单一干提取物。使动物暴露于慢性不可预测的轻度应激8周。通过强迫游泳试验评估抑郁样症状，同时通过新物体识别试验评估记忆缺陷。
抗应激II表现出抗抑郁作用，而抗应激I并未改善抑郁样症状。贯叶连翘和缬草的单一提取物也具有抗抑郁特性。抗应激II改善认知，贯叶连翘、缬草尤其是麻花头的单一提取物也有此作用。麻花头干提取物对识别记忆的效果最佳。抗应激I对记忆缺陷的影响可忽略不计。
抗应激II具有抗抑郁作用并改善识别记忆，而抗应激I未表现出上述任何作用。
