Boklan Jessica L, Walsh Alexandra M, de la Maza Michelina C, Su Leon L, Nizzi Francisco A, Schafernak Kristian T
Division of Hematology/Oncology, Phoenix Children's Hospital.
Department of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, AZ.
J Pediatr Hematol Oncol. 2018 Aug;40(6):456-457. doi: 10.1097/MPH.0000000000001154.
A 10-year-old boy presented with spontaneous bruising and was found to have extreme thrombocytosis without neutrophilia/shift to immaturity, basophilia or eosinophilia. While the peripheral blood and bone marrow findings initially suggested essential thrombocythemia, BCR-ABL1 translocation was detected and chronic myeloid leukemia, chronic phase, was diagnosed. Apheresis for platelet depletion was performed as a bridge given the delayed effects of medical therapy.
一名10岁男孩出现自发性瘀伤，检查发现其血小板极度增多，无中性粒细胞增多/核左移、嗜碱性粒细胞增多或嗜酸性粒细胞增多。虽然外周血和骨髓检查结果最初提示原发性血小板增多症，但检测到BCR-ABL1易位，最终诊断为慢性髓性白血病慢性期。鉴于药物治疗起效延迟，进行了血小板单采术作为过渡治疗。
