Health, Exercise and Active Living Research Centre, Department of Sport and Exercise Sciences, Manchester Metropolitan University Cheshire, Crewe, CW1 5DU, UK.
The Neuromuscular Centre, Winsford, Cheshire, UK.
Muscle Nerve. 2018 Sep;58(3):427-433. doi: 10.1002/mus.26146. Epub 2018 May 17.
The assisted 6-minute cycle test (A6MCT) distance was assessed in adults with muscular dystrophy (MD).
Forty-eight males, including those with Duchenne MD (DMD), limb-girdle MD (LGMD), fascioscapulohumeral MD (FSHD), and Becker MD (BMD), as well as a group without MD (CTRL), completed handgrip strength (HGS), lung function [forced expiratory volume in 1 second (FEV ) and forced vital capacity (FVC)], body fat, and biceps thickness assessments. During the A6MCT, ventilation (VE), oxygen uptake (VO ), carbon dioxide (VCO ), and heart rate (HR) were recorded.
A6MCT and HGS were lower in MD than CTRL subjects. FEV , FVC, and biceps thickness were lower in MD than CTRL; lower in DMD than BMD, LGMD, and FSHD; but were not different between BMD, LGMD, and FSHD. A6MCT correlated with HGS, FEV , FVC, body fat, VO , VCO , HR, and VE (r = 0.455-0.708) in pooled BMD, LGMD, and FSHD participants.
A shorter A6MCT distance in adult males with MD was attributable to HGS and lung function. The A6MCT is appropriate for assessment of physical function in adults with MD. Muscle Nerve 58: 427-433, 2018.
辅助 6 分钟循环测试（A6MCT）距离在患有肌肉营养不良症（MD）的成年人中进行了评估。
48 名男性，包括杜兴氏肌肉营养不良症（DMD）、肢带型肌肉营养不良症（LGMD）、面肩肱型肌肉营养不良症（FSHD）和贝克型肌肉营养不良症（BMD）患者，以及一组无 MD 的对照组（CTRL），完成了握力（HGS）、肺功能[1 秒用力呼气量（FEV ）和用力肺活量（FVC）]、体脂和肱二头肌厚度评估。在 A6MCT 期间，记录了通气量（VE）、氧气摄取量（VO ）、二氧化碳（VCO ）和心率（HR）。
A6MCT 和 HGS 在 MD 患者中低于 CTRL 组。FEV 、FVC 和肱二头肌厚度在 MD 患者中低于 CTRL；在 DMD 患者中低于 BMD、LGMD 和 FSHD；但在 BMD、LGMD 和 FSHD 之间无差异。在 pooled BMD、LGMD 和 FSHD 参与者中，A6MCT 与 HGS、FEV 、FVC、体脂、VO 、VCO 、HR 和 VE（r = 0.455-0.708）相关。
MD 成年男性的 A6MCT 距离较短归因于 HGS 和肺功能。A6MCT 适用于评估 MD 成年患者的身体功能。肌肉神经 58：427-433，2018。
