羊入狼窝：病原菌的故事。

A Hen in the Wolf Den: A Pathobiont Tale.

机构信息

Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute,1-7-22 Suehiro-cho Tsurumi-ku, Yokohama, 230-0045 Kanagawa, Japan.

出版信息

Immunity. 2018 Apr 17;48(4):628-631. doi: 10.1016/j.immuni.2018.04.003.

DOI:10.1016/j.immuni.2018.04.003

PMID:29669247

Abstract

Disruption of the gut microbiota is thought to contribute to disease onset in individuals with a genetic predisposition to autoimmunity. In a recent issue of Science, Manfredo Vieira et al. (2018) identify translocation of the gut commensal Enterococcus gallinarum into the liver as a trigger for the autoimmune disease systemic lupus erythematous.

摘要

肠道微生物群的紊乱被认为有助于具有自身免疫遗传易感性的个体发病。在最近一期的《科学》杂志上，Manfredo Vieira 等人（2018）发现肠道共生菌肠球菌（Enterococcus gallinarum）易位到肝脏是系统性红斑狼疮等自身免疫性疾病的一个诱因。