Tang F, Man S Y
Department of Physiology, Faculty of Medicine, University of Hong Kong.
Proc Soc Exp Biol Med. 1988 May;188(1):82-6. doi: 10.3181/00379727-188-42710.
A comparison of the effect of PTU-induced hypothyroidism on the contents of immunoactive met-enkephalin and beta-endorphin in the pituitaries from rats aged 2 1/2, 12, and 18 months was made. In all ages, there was significant reduction of IR-met-enkephalin content in the anterior lobe and IR-beta-endorphin content in the neuro-intermediate lobe after PTU treatment. There was a significant age-related decrease in IR-beta-endorphin content in the anterior lobe. Rats of all three ages responded to PTU treatment with an increase in serum TSH level and a drastic reduction in serum T3 and T4 levels. The results indicate that there was no age-related difference in the change of pituitary opioid peptide contents in response to hypothyroidism.
对2.5月龄、12月龄和18月龄大鼠垂体中免疫活性甲硫氨酸脑啡肽和β-内啡肽含量，进行了PTU诱导的甲状腺功能减退影响的比较。在所有年龄段，PTU治疗后，前叶中免疫反应性甲硫氨酸脑啡肽含量和神经中间叶中免疫反应性β-内啡肽含量均显著降低。前叶中免疫反应性β-内啡肽含量存在显著的年龄相关下降。所有三个年龄段的大鼠对PTU治疗的反应均为血清促甲状腺激素水平升高，血清T3和T4水平急剧降低。结果表明，对甲状腺功能减退反应时，垂体阿片肽含量的变化不存在年龄相关差异。
