药物性嗜酸性粒细胞增多症
Drug-induced eosinophilia.
作者信息
Rauscher Christine, Freeman Allison
机构信息
From the Department of Hospital Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania.
Department of Allergy and Immunology, Allegheny Health Network, Pittsburgh, Pennsylvania.
出版信息
Allergy Asthma Proc. 2018 May 1;39(3):252-256. doi: 10.2500/aap.2018.39.4120.
BACKGROUND
Drug reactions have been associated with increased blood eosinophil levels.
OBJECTIVE
To review clinical characteristics, the diagnosis, and the management of drug-induced eosinophilia.
METHODS
Pertinent articles were selected and reviewed in relation to a case presentation of drug-induced eosinophilia.
RESULTS
A case of asymptomatic eosinophilia in the setting of acetylsalicylic acid (aspirin) use was presented, followed by discussion of the clinical characteristics, diagnosis, and management of drug-induced eosinophilia. Clinical pearls and pitfalls were reviewed for the practicing allergist, clinical immunologist, and fellow-in-training.
CONCLUSION
Drug-induced eosinophilia is a diagnosis of exclusion. Although most cases of drug-induced eosinophilia are asymptomatic, one study showed an increased rate of hypersensitivity reactions in patients with higher eosinophil counts and earlier onset of eosinophilia.
背景
药物反应与血液嗜酸性粒细胞水平升高有关。
目的
回顾药物性嗜酸性粒细胞增多症的临床特征、诊断及管理。
方法
结合一例药物性嗜酸性粒细胞增多症的病例报告，选择并回顾相关文章。
结果
报告了一例在使用乙酰水杨酸（阿司匹林）情况下出现的无症状嗜酸性粒细胞增多症病例，随后讨论了药物性嗜酸性粒细胞增多症的临床特征、诊断及管理。为执业过敏症专科医生、临床免疫学家及实习医生复习了临床要点和陷阱。
结论
药物性嗜酸性粒细胞增多症是一种排除性诊断。虽然大多数药物性嗜酸性粒细胞增多症病例无症状，但一项研究表明，嗜酸性粒细胞计数较高且嗜酸性粒细胞增多症发病较早的患者发生过敏反应的几率增加。
Zotero 插件