高血嗜酸性粒细胞计数可预测重度哮喘患者的痰液嗜酸性粒细胞增多。 - Suppr

High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma.

作者信息

Fowler Stephen J, Tavernier Gaël, Niven Robert

机构信息

University of Manchester, Manchester Academic Health Science Centre, and NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester, Manchester, United Kingdom; Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom.

出版信息

J Allergy Clin Immunol. 2015 Mar;135(3):822-4.e2. doi: 10.1016/j.jaci.2014.09.034. Epub 2014 Oct 30.

DOI:10.1016/j.jaci.2014.09.034

PMID:25445828

Abstract

摘要

相似文献

High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma.高血嗜酸性粒细胞计数可预测重度哮喘患者的痰液嗜酸性粒细胞增多。

J Allergy Clin Immunol. 2015 Mar;135(3):822-4.e2. doi: 10.1016/j.jaci.2014.09.034. Epub 2014 Oct 30.

Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma.局部嗜酸性粒细胞生成过程在泼尼松依赖型重度哮喘气道嗜酸性粒细胞增多症发生中的作用

Clin Exp Allergy. 2016 Jun;46(6):793-802. doi: 10.1111/cea.12695.

Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma.血液嗜酸性粒细胞计数是一种有用的生物标志物，可用于识别患有严重嗜酸性粒细胞性哮喘的患者。

Ann Am Thorac Soc. 2014 May;11(4):531-6. doi: 10.1513/AnnalsATS.201310-354OC.

Inhaled fluticasone propionate is effective as well as oral prednisone in reducing sputum eosinophilia during exacerbations of asthma which do not require hospitalization.在哮喘发作且无需住院治疗期间，吸入丙酸氟替卡松在降低痰液嗜酸性粒细胞方面与口服泼尼松同样有效。

Pulm Pharmacol Ther. 2006;19(5):353-60. doi: 10.1016/j.pupt.2005.09.003. Epub 2005 Nov 11.

Biomarkers for severe eosinophilic asthma.严重嗜酸性粒细胞性哮喘的生物标志物。

J Allergy Clin Immunol. 2017 Dec;140(6):1509-1518. doi: 10.1016/j.jaci.2017.10.005.

The effect of montelukast on eosinophil apoptosis: induced sputum findings of patients with mild persistent asthma.孟鲁司特对嗜酸性粒细胞凋亡的影响：轻度持续性哮喘患者诱导痰的研究结果

Allergol Immunopathol (Madr). 2005 Mar-Apr;33(2):105-11. doi: 10.1157/13072922.

Emerging Biologics in Severe Asthma.重度哮喘中的新兴生物制剂

Immunol Allergy Clin North Am. 2016 Aug;36(3):609-23. doi: 10.1016/j.iac.2016.04.001.

Can we predict sputum eosinophilia from clinical assessment in patients referred to an adult asthma clinic?我们能否通过临床评估预测转诊至成人哮喘门诊患者的痰嗜酸性粒细胞增多症？

Intern Med J. 2013 Jan;43(1):46-52. doi: 10.1111/j.1445-5994.2011.02565.x.

Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma.孟鲁司特在高剂量糖皮质激素依赖型哮喘中未能降低痰液嗜酸性粒细胞水平。

Eur Respir J. 2005 Jan;25(1):41-6. doi: 10.1183/09031936.04.00008104.

Mepolizumab use: Post-approval academic practice experience.美泊利单抗的使用：批准后学术实践经验

Ann Allergy Asthma Immunol. 2018 Jul;121(1):126-128. doi: 10.1016/j.anai.2018.04.001. Epub 2018 Apr 10.

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Targeted Biologic Therapies in Severe Asthma: Mechanisms, Biomarkers, and Clinical Applications.重度哮喘的靶向生物疗法：作用机制、生物标志物及临床应用

Pharmaceuticals (Basel). 2025 Jul 10;18(7):1021. doi: 10.3390/ph18071021.

Predictors of asthma exacerbation between high and low blood eosinophil counts.高、低血嗜酸性粒细胞计数之间哮喘加重的预测因素。

ERJ Open Res. 2025 Jul 7;11(4). doi: 10.1183/23120541.01218-2024. eCollection 2025 Jul.

Peripheral eosinophil count as a biomarker for asthma exacerbation severity in acute care settings.在急性护理环境中，外周血嗜酸性粒细胞计数作为哮喘急性加重严重程度的生物标志物。

Ann Allergy Asthma Immunol. 2025 Jul;135(1):63-70.e3. doi: 10.1016/j.anai.2025.04.005. Epub 2025 Apr 19.

The Phenotypes of Asthma-Bronchiectasis Overlap: Clinical Characteristics and Outcomes.哮喘-支气管扩张重叠综合征的表型：临床特征与转归

Allergy Asthma Immunol Res. 2025 Mar;17(2):196-211. doi: 10.4168/aair.2025.17.2.196.

Moderate-High Blood Eosinophilia Is Associated with Increased Hospitalization and Other Asthma Comorbidities.中重度血嗜酸性粒细胞增多与住院和其他哮喘合并症增加有关。

Biomolecules. 2024 Jan 18;14(1):126. doi: 10.3390/biom14010126.

Association between Childhood Asthma Control Test scores and lung pathophysiologic indicators in longitudinal measurements.纵向测量中儿童哮喘控制测试分数与肺病理生理指标之间的关联。

J Thorac Dis. 2023 Aug 31;15(8):4207-4215. doi: 10.21037/jtd-22-1383. Epub 2023 Jul 28.

Inhaled drug delivery for the targeted treatment of asthma.吸入式药物输送在哮喘靶向治疗中的应用。

Adv Drug Deliv Rev. 2023 Jul;198:114858. doi: 10.1016/j.addr.2023.114858. Epub 2023 May 12.

Association between serum folate levels and blood eosinophil counts in American adults with asthma: Results from NHANES 2011-2018.美国成年人哮喘患者血清叶酸水平与血嗜酸性粒细胞计数的相关性：NHANES 2011-2018 研究结果。

Front Immunol. 2023 Feb 22;14:1134621. doi: 10.3389/fimmu.2023.1134621. eCollection 2023.

Association between Exposure to Selected Heavy Metals and Blood Eosinophil Counts in Asthmatic Adults: Results from NHANES 2011-2018.成年哮喘患者接触特定重金属与血液嗜酸性粒细胞计数之间的关联：2011 - 2018年美国国家健康与营养检查调查结果

J Clin Med. 2023 Feb 15;12(4):1543. doi: 10.3390/jcm12041543.

Rethinking blood eosinophil counts: Epidemiology, associated chronic diseases, and increased risks of cardiovascular disease.重新审视血液嗜酸性粒细胞计数：流行病学、相关慢性疾病及心血管疾病风险增加

J Allergy Clin Immunol Glob. 2022 Nov;1(4):233-240. doi: 10.1016/j.jacig.2022.09.001. Epub 2022 Sep 12.

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High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma.

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