Karolyi J, Erickson R P, Liu S
Department of Human Genetics, University of Michigan, Ann Arbor 49109-0618.
Teratology. 1988 Mar;37(3):283-7. doi: 10.1002/tera.1420370314.
In a search for genetic differences in susceptibility to cleft palate, congenic and recombinant inbred strains of mice were treated with 6-aminonicotinamide or control injections. Of six loci tested, only the chromosome segment marked by N-acetyl transferase was found to affect susceptibility to 6-aminonicotinamide-induced cleft palate. This chromosome segment is known to affect glucocorticoid-induced cleft palate and phenytoin-induced cleft lip with or without cleft palate in these strains of mice.
为了寻找腭裂易感性的基因差异，对同源近交系和重组近交系小鼠进行6-氨基烟酰胺处理或对照注射。在所测试的6个基因座中，只有由N-乙酰转移酶标记的染色体片段被发现影响对6-氨基烟酰胺诱导的腭裂的易感性。已知该染色体片段在这些品系的小鼠中会影响糖皮质激素诱导的腭裂以及苯妥英诱导的唇裂伴或不伴腭裂。
