Centre for Infectious Disease Control - Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, 3720 BA, Bilthoven, Netherlands.
Department of Public Health and Surveillance, Scientific Institute of Public Health (WIV-ISP), 1050, Brussels, Belgium.
Sci Rep. 2018 Apr 18;8(1):6218. doi: 10.1038/s41598-018-24361-8.
Primary Toxoplasma gondii infection in pregnant women may result in abortion, stillbirth, or lifelong disabilities of the unborn child. One of the main transmission routes to humans is consumption of raw or undercooked meat containing T. gondii tissue cysts. We aim to determine and compare the regional distribution of T. gondii seroprevalence in pregnant women and meat-producing livestock in China through a systematic literature review. A total of 272 eligible publications were identified from Medline, Scopus, Embase and China National Knowledge Infrastructure. Apparent and true seroprevalence were analysed by region using a novel Bayesian hierarchical model that allowed incorporating sensitivity and specificity of the applied serological assays. The true seroprevalence of T. gondii in pregnant women was 5.0% or less in seven regions of China. The median of the regional true seroprevalences in pigs (24%) was significantly higher than in cattle (9.5%), but it was not significantly higher than in chickens (20%) and small ruminants (20%). This study represents the first use of a Bayesian hierarchical model to obtain regional true seroprevalence. These results, in combination with meat consumption data, can be used to better understand the contribution of meat-producing animals to human T. gondii infection in China.
孕妇原发性弓形体病感染可能导致流产、死产或胎儿终身残疾。人类感染的主要传播途径之一是食用含有弓形体组织囊的生肉或未煮熟的肉。我们旨在通过系统文献综述，确定并比较中国孕妇和肉用家畜弓形体血清阳性率的区域分布。从 Medline、Scopus、Embase 和中国国家知识基础设施中确定了 272 篇符合条件的出版物。使用一种新颖的贝叶斯层次模型，根据区域分析明显和真实的血清阳性率，该模型允许纳入应用血清学检测的敏感性和特异性。中国 7 个地区孕妇弓形体真实血清阳性率均低于 5.0%。猪（24%）的区域真实血清阳性率中位数明显高于牛（9.5%），但高于鸡（20%）和小反刍动物（20%）。本研究首次使用贝叶斯层次模型获得了区域真实血清阳性率。这些结果结合肉类消费数据，可以更好地了解中国肉用动物对人类弓形体感染的贡献。
