大动脉转位新生儿的心房利钠肽与心房压力

Atrial natriuretic peptide and atrial pressures in newborns with transposition of the great arteries.

作者信息

Andersson S, Tikkanen I, Pesonen E, Wallgren E I, Fyhrquist F

机构信息

Department of Medical Chemistry, University of Helsinki, Finland.

出版信息

Acta Paediatr Scand. 1988 Jan;77(1):72-5. doi: 10.1111/j.1651-2227.1988.tb10600.x.

DOI:10.1111/j.1651-2227.1988.tb10600.x

PMID:2967024

Abstract

The relation of atrial pressure to atrial plasma concentration of atrial natriuretic peptide (ANP) was studied in four newborns undergoing catheterization because of transposition of the great arteries. In three patients, mean left atrial pressure clearly exceeded right atrial pressure (12 +/- 7 vs. 2 +/- 3 mmHg; mean +/- SD). In one patient mean atrial pressures were identical (4 mmHg). In all patients the ANP concentration in the left atrium exceeded that of the right (833 +/- 464 vs. 415 +/- 366 pg/ml; mean +/- SD). There was a significant (r = 0.97; p less than 0.01) correlation between pressure and ANP concentration in the left atria. In the right atria, no linear correlation existed between pressure and ANP concentration. ANP concentration in the left atrium decreased after a lowering of the left atrial pressure by atrial septostomy. In these patients, the left atrium seems to be the main source of circulating ANP.

摘要

对4例因大动脉转位接受心导管插入术的新生儿，研究了心房压力与心房利钠肽（ANP）血浆浓度的关系。3例患者，平均左心房压力明显超过右心房压力（12±7对2±3 mmHg；均值±标准差）。1例患者平均心房压力相同（4 mmHg）。所有患者左心房的ANP浓度均超过右心房（833±464对415±366 pg/ml；均值±标准差）。左心房压力与ANP浓度之间存在显著相关性（r = 0.97；p<0.01）。在右心房，压力与ANP浓度之间不存在线性相关性。经房间隔造口术降低左心房压力后，左心房的ANP浓度下降。在这些患者中，左心房似乎是循环中ANP的主要来源。