Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112-5550, USA.
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA.
Br J Cancer. 2018 May;118(11):1513-1517. doi: 10.1038/s41416-018-0075-0. Epub 2018 Apr 19.
Telomeres protect cells from genomic instability. We examined telomere length and lung cancer risk prospectively in heavy smokers.
In a nested case-control study with 709 cases and 1313 controls, conditional logistic regression was used to evaluate associations between telomere length (global, chromosome 5p, and 13q) and lung cancer risk by histotype, controlling for detailed smoking history.
Risks of overall lung cancer and adenocarcinoma were suggestively elevated among individuals with telomere length in the longest tertile. No clear patterns were observed for other histotypes, or for chromosome 5p or 13q telomere length. Associations with adenocarcinoma were strongest among (OR, 95% CI for longest versus shortest tertile): former smokers (2.26, 1.03-4.96), individuals <65 years (2.22, 1.13-4.35), and women (2.21, 0.99-4.93).
Our large study of heavy smokers adds additional evidence that long telomere length prior to diagnosis is associated with risk of lung adenocarcinoma, but not other histotypes.
端粒可保护细胞免受基因组不稳定的影响。我们前瞻性地研究了端粒长度与重度吸烟者肺癌风险之间的关系。
在一项包含 709 例病例和 1313 例对照的巢式病例对照研究中，采用条件 logistic 回归，通过详细的吸烟史控制，评估了端粒长度（总体、染色体 5p 和 13q）与肺癌风险之间的关联，并按组织学类型进行分层分析。
与端粒长度处于最长三分之一的个体相比，总体肺癌和腺癌的风险呈升高趋势，但其他组织学类型或染色体 5p 或 13q 端粒长度未见明显模式。与腺癌的关联在以下人群中最强：前吸烟者（2.26，1.03-4.96）、<65 岁者（2.22，1.13-4.35）和女性（2.21，0.99-4.93）。
我们对重度吸烟者进行的大型研究进一步表明，诊断前较长的端粒长度与肺腺癌风险相关，但与其他组织学类型无关。
