调节免疫反应并促进细胞内死亡。
Modulates the Immune Response and Promotes Intracellular Death.
机构信息
Graduate Program in Bioscience and Physiopathology, Departamento de Análises Clínicas e Biomedicina, The State University of Maringá, Colombo Avenue 5790, 87020-900 Maringá, PR, Brazil.
Departamento de Análises Clínicas e Biomedicina, The State University of Maringá, Maringá, PR, Brazil.
出版信息
Mediators Inflamm. 2018 Feb 13;2018:6148351. doi: 10.1155/2018/6148351. eCollection 2018.
is a plant from the Brazilian rain forests and has been used in folk medicine for the treatment of various diseases, including leishmaniasis. This infectious disease depends on the sp. and the host immune response. antileishmanial activity is well known, but the effects on immune response remain to be investigated. This study showed the leishmanicidal and immunomodulatory effects of a 30 g/mL of hydroalcoholic extract of in murine macrophages before and after () infection. The semiquantitative cytokine RNA expression was determined by RT-PCR and the anti- activity was measured by infection index (IF). Hydroalcoholic extract of reduced more than 95% of IF when used before and after infection, with 3 and 24 h of treatment ( < 0.05). inhibited or reduced significantly ( < 0.05) the TNF-, IL-1, IL-18, and IL-10 mRNA expression. The antileishmanial and anti-inflammatory effects showed the potential of as an alternative therapy for leishmaniasis and it must be investigated.
是一种来自巴西雨林的植物，在民间医学中被用于治疗各种疾病，包括利什曼病。这种传染病依赖于 sp. 和宿主的免疫反应。 具有抗利什曼原虫活性，但对免疫反应的影响仍有待研究。本研究在感染前后检测了 30μg/mL 水醇提巴西苏木素对小鼠巨噬细胞的杀利什曼原虫和免疫调节作用。通过 RT-PCR 测定半定量细胞因子 RNA 表达，通过感染指数（IF）测定抗感染活性。水醇提巴西苏木素在感染前后使用时可使 IF 降低超过 95%，处理 3 和 24 小时（<0.05）。它显著抑制或降低（<0.05）TNF-α、IL-1、IL-18 和 IL-10 的 mRNA 表达。抗利什曼原虫和抗炎作用显示了巴西苏木素作为利什曼病替代疗法的潜力，需要进一步研究。
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