Yu Jing, Ye Hui, Li Jiang, Li Ning, Shi Zong-Ming, Zhang Xue-Zhi
Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China.
Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China.
Evid Based Complement Alternat Med. 2018 Feb 12;2018:1491732. doi: 10.1155/2018/1491732. eCollection 2018.
(, CGL) was investigated for activities against both and . The agar dilution method and time-kill curves, as assays and an study using a Kunming mice model, were performed. CGL demonstrated a strong anti- activity with the minimal inhibitory concentrations (MICs) against multiple strains of 0.5~8 mg/ml and the decreasing trend time-kill curves when increasing CGL concentrations. eradication rates were evaluated based on rapid urease test (RUT) and histopathologic criteria. Results revealed that the eradication rates in the CGL groups were 40% (4/10) in the high dosage group, 33% (4/11) in the medium dosage group, and 18% (2/11) in the low dosage group, with the difference between the high dosage and control groups being significant ( = 0.035). The colonization scores could be reduced partly by CGL. These results demonstrated that CGL in a rationally high dosage might be the most effective.
研究了[具体名称，CGL]对[两种细菌名称]的抗菌活性。采用琼脂稀释法和时间杀菌曲线，以及[具体检测方法]检测和利用昆明小鼠模型进行[具体研究类型]研究。CGL对[目标细菌名称]显示出较强的抗菌活性，对多种[目标细菌名称]菌株的最低抑菌浓度（MICs）为0.5~8mg/ml，且随着CGL浓度增加，时间杀菌曲线呈下降趋势。根据快速尿素酶试验（RUT）和组织病理学标准评估[细菌名称]根除率。结果显示，高剂量组CGL组的根除率为40%（4/10），中剂量组为33%（4/11），低剂量组为18%（2/11），高剂量组与对照组之间差异有统计学意义（P = 0.035）。CGL可部分降低[细菌名称]定植分数。这些结果表明，合理的高剂量CGL可能是最有效的。
