模型水提取物的镇痛和抗炎活性评价。
Evaluation of Analgesic and Anti-Inflammatory Activities of Water Extract of Models.
作者信息
Sun Kai, Song Xu, Jia RenYong, Yin Zhongqiong, Zou Yuanfeng, Li Lixia, Yin Lizi, He Changliang, Liang Xiaoxia, Yue Guizhou, Cui Qiankun, Yang Yi
机构信息
Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
出版信息
Evid Based Complement Alternat Med. 2018 Feb 18;2018:6784032. doi: 10.1155/2018/6784032. eCollection 2018.
AIM
Pain and inflammation are associated with many diseases in humans and animals. , a traditional Chinese medicine, has a variety of pharmacological properties. The purpose of this study was to evaluate analgesic and anti-inflammatory activities of through different animal models.
METHOD
The analgesic activities were evaluated by hot-plate and writhing tests. The anti-inflammatory effects were assessed by ear edema, capillary permeability, and paw edema tests. The contents of cytokines (NO, iNOS, PGE, and IL-10) in serum of rats in paw edema test were inspected by ELISA assays.
RESULTS
In the hot-plate test, could significantly extend pain threshold when compared to control group. The inhibitory rates of writhes ranged from 36.62% to 68.57% in -treated mice. Treatment with (1 and 0.5 g/kg) could significantly inhibit ear edema (47.45 and 36.91%, resp.; < 0.01). (1 g/kg) had significant ( < 0.05) anti-inflammatory activity in capillary permeability test (29.04%). In carrageenan-induced edema test, the inhibitory rates were 43.71% and 44.07% ( < 0.01) at 1 h and 2 h after administration of (1 g/kg), respectively, and the levels of proinflammatory cytokines were significantly reduced.
CONCLUSION
These results suggest that has analgesic and anti-inflammatory effects, which may be a candidate drug for the treatment of inflammation and pain.
目的
疼痛和炎症与人类和动物的多种疾病相关。中药[具体中药名称未给出]具有多种药理特性。本研究的目的是通过不同动物模型评估[具体中药名称未给出]的镇痛和抗炎活性。
方法
通过热板法和扭体试验评估镇痛活性。通过耳肿胀、毛细血管通透性和足肿胀试验评估抗炎作用。采用酶联免疫吸附测定法检测足肿胀试验中大鼠血清中细胞因子（一氧化氮、诱导型一氧化氮合酶、前列腺素E和白细胞介素 - 10）的含量。
结果
在热板试验中，与对照组相比，[具体中药名称未给出]可显著延长痛阈。在[具体中药名称未给出]处理的小鼠中，扭体抑制率在36.62%至68.57%之间。用[具体中药名称未给出]（1和0.5 g/kg）处理可显著抑制耳肿胀（分别为47.45%和36.91%；P<0.01）。[具体中药名称未给出]（1 g/kg）在毛细血管通透性试验中具有显著（P<0.05）抗炎活性（29.04%）。在角叉菜胶诱导的肿胀试验中，给予[具体中药名称未给出]（1 g/kg）后1小时和2小时的抑制率分别为43.71%和44.07%（P<0.01），促炎细胞因子水平显著降低。
结论
这些结果表明[具体中药名称未给出]具有镇痛和抗炎作用，可能是治疗炎症和疼痛的候选药物。
Zotero 插件