Alhalel N, Schueller S M, O'Brien M J
Northwestern University Feinberg School of Medicine Chicago IL USA.
Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL USA.
Obes Sci Pract. 2018 Mar 14;4(2):153-158. doi: 10.1002/osp4.157. eCollection 2018 Apr.
This study examined changes in mental health symptoms and weight during weight loss treatment. It was hypothesized that worsening mental health would negatively impact weight loss.
Data were analyzed from a trial of 92 Hispanic women with overweight/obesity and prediabetes, who were randomized to receive intensive lifestyle intervention (ILI), metformin 1,700 mg daily, or standard care. Depression, anxiety and perceived stress were assessed at 0, 6 and 12 months. Six- and 12-month weight change was compared among participants whose symptom scores worsened on any mental health measure (W) vs. improved or remained stable on all three (I/S).
Among ILI participants, the 12-month difference in weight loss between I/S and W groups was statistically significant: -5.1 kg (P = 0.001). From baseline to 6 months, ILI participants in I/S and W groups experienced comparable weight loss. However, from 6 to 12 months, W participants regained weight, whereas I/S participants experienced continued weight loss. In the metformin and standard care arms, there was no weight difference between I/S and W groups.
In ILI, 12-month improvement or stability in mental health was significantly associated with weight loss. Weight trajectories between I/S and W groups diverged at 6 months.
本研究调查了减肥治疗期间心理健康症状和体重的变化。研究假设心理健康状况恶化会对体重减轻产生负面影响。
对92名患有超重/肥胖症和糖尿病前期的西班牙裔女性进行的一项试验数据进行了分析，这些女性被随机分配接受强化生活方式干预（ILI）、每日1700毫克二甲双胍或标准护理。在0、6和12个月时评估抑郁、焦虑和感知压力。比较了在任何心理健康指标上症状评分恶化的参与者（W）与在所有三项指标上症状评分改善或保持稳定的参与者（I/S）在6个月和12个月时的体重变化。
在ILI参与者中，I/S组和W组在12个月时的体重减轻差异具有统计学意义：-5.1千克（P = 0.001）。从基线到6个月，I/S组和W组的ILI参与者体重减轻情况相当。然而，从6个月到12个月，W组参与者体重反弹，而I/S组参与者体重持续减轻。在二甲双胍和标准护理组中，I/S组和W组之间没有体重差异。
在ILI中，心理健康在12个月时的改善或稳定与体重减轻显著相关。I/S组和W组之间的体重轨迹在6个月时出现分歧。
