Obiorah Ifeyinwa E, Kyrillos Alexandra, Ozdemirli Metin
Department of Pathology, MedStar Georgetown University Hospital, Washington, DC, USA.
Case Rep Urol. 2018 Feb 19;2018:8747131. doi: 10.1155/2018/8747131. eCollection 2018.
Leydig cell tumor is a rare sex cord tumor that accounts for 1-3% of all testicular neoplasms. Seminomas are more common and occur in 30-40% of testicular tumors. Leydig cell tumors are derived from undifferentiated gonadal mesenchyme and the concurrent development of the tumor and a seminoma which are derived from germinal epithelium in an ipsilateral testis is extremely rare. Here we report a case of ipsilateral Leydig cell tumor and seminoma occurring in a 38-year-old man with a left testicular mass. The key to diagnosis is dependent on histopathology and immunohistochemistry. To our knowledge, this is the first diagnosis of the two disease entities in a unilateral testis using immunohistochemistry. Increased awareness of the entity is important in order to distinguish Leydig cell tumor and seminomas from other malignancies due to difference in therapeutic management.
睾丸间质细胞瘤是一种罕见的性索肿瘤，占所有睾丸肿瘤的1%-3%。精原细胞瘤更为常见，占睾丸肿瘤的30%-40%。睾丸间质细胞瘤起源于未分化的性腺间充质，而肿瘤与精原细胞瘤（起源于同侧睾丸的生发上皮）同时发生极为罕见。本文报告一例38岁男性左侧睾丸肿块患者，其同侧发生睾丸间质细胞瘤和精原细胞瘤。诊断的关键取决于组织病理学和免疫组织化学。据我们所知，这是首次通过免疫组织化学在单侧睾丸中诊断出这两种疾病实体。由于治疗管理存在差异，提高对该实体的认识对于将睾丸间质细胞瘤和精原细胞瘤与其他恶性肿瘤区分开来很重要。
