Savari Omid, Hastings Hope, Rayes Rania, Tomashefski Joseph F
1 Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA.
Int J Surg Pathol. 2018 Oct;26(7):660-663. doi: 10.1177/1066896918769745. Epub 2018 Apr 19.
Carcinoid tumorlets are peribronchiolar proliferations of neuroendocrine cells often associated with lung scars. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a non-Hodgkin's lymphoma that frequently involves the gastrointestinal tract but less commonly is described in the lung. Simultaneous occurrence of neuroendocrine neoplasms and MALT lymphoma is extraordinarily rare and has predominately been reported in the gastrointestinal tract. In this article, we describe the case of a 73-year-old female with coexisting pulmonary MALT lymphoma and carcinoid tumorlets of the right middle lobe. Retrospective series of 8 pulmonary MALT lymphomas are evaluated for neuroendocrine neoplasia by immunohistochemistry. No correlation between MALT lymphoma and neuroendocrine neoplasia was identified in this case series. While the concurrence of these distinctive neoplasms is most likely coincidental, the presence of a common risk factor, or one neoplasm as a risk factor for the other, deserves study of a larger group of pulmonary MALT lymphomas.
类癌小结是神经内分泌细胞的支气管周围增生，常与肺瘢痕相关。黏膜相关淋巴组织结外边缘区淋巴瘤（MALT淋巴瘤）是一种非霍奇金淋巴瘤，常累及胃肠道，但较少见于肺部。神经内分泌肿瘤与MALT淋巴瘤同时发生极为罕见，主要报道于胃肠道。在本文中，我们描述了一例73岁女性患者，其右中叶同时存在肺MALT淋巴瘤和类癌小结。对8例肺MALT淋巴瘤的回顾性系列病例进行免疫组化评估，以检测神经内分泌肿瘤形成情况。在该病例系列中，未发现MALT淋巴瘤与神经内分泌肿瘤形成之间存在相关性。虽然这些独特肿瘤的同时出现很可能是巧合，但存在共同危险因素，或一种肿瘤作为另一种肿瘤的危险因素，值得对更大组的肺MALT淋巴瘤进行研究。
