Neurosurgery Department, University of Heidelberg, Heidelberg, Germany.
J Cereb Blood Flow Metab. 2018 Jul;38(7):1149-1179. doi: 10.1177/0271678X18771440. Epub 2018 Apr 20.
Spreading depolarization (SD) occurs alongside brain injuries and it can lead to neuronal damage. Therefore, pharmacological modulation of SD can constitute a therapeutic approach to reduce its detrimental effects and to improve the clinical outcome of patients. The major objective of this article was to produce a systematic review of all the drugs that have been tested against SD. Of the substances that have been examined, most have been shown to modulate certain SD characteristics. Only a few have succeeded in significantly inhibiting SD. We present a variety of strategies that have been proposed to overcome the notorious harmfulness and pharmacoresistance of SD. Information on clinically used anesthetic, sedative, hypnotic agents, anti-migraine drugs, anticonvulsants and various other substances have been compiled and reviewed with respect to the efficacy against SD, in order to answer the question of whether a drug at safe doses could be of therapeutic use against SD in humans.
扩散性去极化（SD）与脑损伤同时发生，可能导致神经元损伤。因此，SD 的药理学调节可能构成一种治疗方法，以减少其有害影响并改善患者的临床结果。本文的主要目的是对所有针对 SD 进行测试的药物进行系统评价。在所检查的物质中，大多数物质已被证明可以调节某些 SD 特征。只有少数药物成功地显著抑制了 SD。我们提出了各种策略来克服 SD 的恶名昭著的危害性和药物抗性。已经编译了关于临床使用的麻醉剂、镇静剂、催眠剂、抗偏头痛药物、抗惊厥药物和各种其他物质的信息，并对其针对 SD 的疗效进行了审查，以回答一个问题，即在安全剂量下的药物是否可以对人类的 SD 具有治疗作用。
