Reynolds G P, Pearson S J, Halket J, Sandler M
Department of Pathology, University of Nottingham Medical School, Queen's Medical Centre, England.
J Neurochem. 1988 Jun;50(6):1959-60. doi: 10.1111/j.1471-4159.1988.tb02503.x.
Concentrations of the endogenous neurotoxic tryptophan metabolite, quinolinic acid (QA), were measured in postmortem brain tissue obtained from patients with Huntington's disease (HD) and matched controls, using a gas chromatography/mass spectrometry method. There was no significant difference in either the putamen or the frontal cortex between the HD and control groups. These results do not support the hypothesis that increased QA is responsible for neuronal degeneration in HD.
采用气相色谱/质谱法，对亨廷顿病（HD）患者及匹配的对照组的死后脑组织中内源性神经毒性色氨酸代谢产物喹啉酸（QA）的浓度进行了测定。HD组和对照组之间，壳核或额叶皮质中的QA浓度均无显著差异。这些结果并不支持QA增加是导致HD患者神经元变性原因的假说。
