Heyes M P, Garnett E S, Brown R R
Life Sci. 1985 Nov 11;37(19):1811-6. doi: 10.1016/0024-3205(85)90223-1.
We measured the excretion of the endogenous neurotoxin quinolinic acid in 14 patients with Huntington's disease and in 11 age matched control subjects. Huntingtonian patients excreted less quinolinic acid, than controls. When normalised to urea or creatinine output quinolinic acid excretion was normal. We conclude that Huntington's disease is not associated with a generalised disturbance of quinolinic acid metabolism, however, a local hyperproduction of quinolinic acid cannot be excluded from our results.
我们测定了14例亨廷顿病患者及11例年龄匹配的对照者体内内源性神经毒素喹啉酸的排泄情况。亨廷顿病患者排泄的喹啉酸比对照组少。当以尿素或肌酐排出量进行标准化后，喹啉酸排泄量正常。我们得出结论，亨廷顿病与喹啉酸代谢的全身性紊乱无关，然而，根据我们的结果不能排除喹啉酸局部过量产生的情况。
