13-顺式维甲酸对血卟啉衍生物诱导的细胞体外光敏感性的保护作用。
Protective effect of 13-cis-retinoic acid on hematoporphyrin derivative-induced cell photosensitivity in vitro.
作者信息
Szaniawska B, Janik P, Ostrowski J, Graczyk A
机构信息
Department of Tumor Biology, Cancer Center of the Maria Skłodowska-Curie Institute, Warsaw, Poland.
出版信息
Neoplasma. 1988;35(2):191-5.
PMID:2967440
Abstract
The influence of 13-cis-retinoic acid on the light-caused injury of hematoporphyrin-pretreated nontransformed 10 T1/2 fibroblasts and N2a neuroblastoma cells was investigated. Retinoid reduced the percentage of damaged cells as assessed by the plating efficiency assay. N2a neuroblastoma cells were found to be better protected than 10 T1/2 cells by 13-cis-retinoic acid on hematoporphyrin light-induced injury.
摘要
研究了13-顺式维甲酸对血卟啉预处理的未转化10 T1/2成纤维细胞和N2a神经母细胞瘤细胞光致损伤的影响。通过平板接种效率测定法评估，类视黄醇降低了受损细胞的百分比。发现在血卟啉光诱导损伤方面，13-顺式维甲酸对N2a神经母细胞瘤细胞的保护作用优于10 T1/2细胞。
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