Lu M, Zheng F, Huang H N
Beijing Medical University.
Zhonghua Zhong Liu Za Zhi. 1987 Sep;9(5):325-7, 19.
In this paper, light and electron micrographs of Ehrlich ascites tumor cells radiated by gamma-ray and influenced by hematoporphyrin derivative (HPD) were analysed by morphometric method. It was found that in these cells, the domain of microfilaments treated by HPD expanded extensively, which enhanced the damage of cells induced by gamma-ray. Twenty five minutes after radiation, the cellular fragments increased, resulting in a decrease in the mean diameter of cells and an increase of nuclear volume density and nucleocytoplasmic ratio. In addition, ribosomes on the rough endoplasmic reticulum surfaces fell off increasingly and the quantity of smooth endoplasmic reticula increased.
本文采用形态计量学方法，分析了经γ射线辐射并受血卟啉衍生物（HPD）影响的艾氏腹水癌细胞的光镜和电镜照片。结果发现，在这些细胞中，经HPD处理的微丝区域广泛扩展，这增强了γ射线诱导的细胞损伤。辐射后25分钟，细胞碎片增多，导致细胞平均直径减小，核体积密度和核质比增加。此外，粗面内质网表面的核糖体越来越多地脱落，滑面内质网数量增加。
