乙烯基类似物的卡泰拉尼反应：一项计算与实验相结合的研究。
The vinylogous Catellani reaction: a combined computational and experimental study.
作者信息
Yamamoto Y, Murayama T, Jiang J, Yasui T, Shibuya M
机构信息
Department of Basic Medicinal Sciences , Graduate School of Pharmaceutical Sciences , Nagoya University , Chikusa , Nagoya 464-8601 , Japan . Email:
出版信息
Chem Sci. 2017 Nov 30;9(5):1191-1199. doi: 10.1039/c7sc04265e. eCollection 2018 Feb 7.
In the presence of 5 mol% Pd(OAc), 1 equiv. of norbornene, and KCO, the reaction of 4-iodo-2-quinolones with tertiary -bromobenzylic alcohols produced the desired benzopyran-fused 2-quinolones in moderate to high yields. A Catellani-type mechanism involving vinylic C-H cleavage is proposed based on the results of control experiments and density functional theory calculations.
在5 mol%醋酸钯、1当量降冰片烯和碳酸钾存在下，4-碘-2-喹诺酮与叔溴代苄醇反应，以中等至高产率生成所需的苯并吡喃稠合2-喹诺酮。基于对照实验结果和密度泛函理论计算，提出了一种涉及乙烯基C-H裂解的卡泰拉尼型机理。
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