利用生物学特性实现乳腺癌放疗个性化：从实验室到加速器
Personalizing Breast Cancer Irradiation Using Biology: From Bench to the Accelerator.
作者信息
Azria David, Brengues Muriel, Gourgou Sophie, Bourgier Celine
机构信息
Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Montpellier, France.
Université de Montpellier, Montpellier, France.
出版信息
Front Oncol. 2018 Apr 5;8:83. doi: 10.3389/fonc.2018.00083. eCollection 2018.
Abstract
While adjuvant treatments of early breast cancers (BCs) had significantly improved patients' overall survival, some of them will still develop locoregional relapses and/or severe late radio-induced toxicities. Here, we propose to review how to personalize locoregional treatment by identifying patients at high and low risk of locoregional relapse, patients at risk of late radio-induced side effects. We will, therefore, discuss how to enhance BC radiosensitivity. Finally, we will address how personalized radiotherapy could be implemented in prospective clinical trials.
摘要
虽然早期乳腺癌（BC）的辅助治疗显著提高了患者的总生存率，但其中一些患者仍会出现局部区域复发和/或严重的晚期放射性毒性。在此，我们建议回顾如何通过识别局部区域复发高风险和低风险患者、有晚期放射性副作用风险的患者来实现局部区域治疗的个性化。因此，我们将讨论如何提高乳腺癌的放射敏感性。最后，我们将探讨如何在前瞻性临床试验中实施个性化放疗。
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