大鼠肩袖修复后滑囊组织间充质干细胞的迁移
Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats.
作者信息
Safi Elem, Ficklscherer Andreas, Bondarava Maryna, Betz Oliver, Zhang Anja, Jansson Volkmar, Müller Peter E
机构信息
Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Munich, Germany.
出版信息
Joints. 2018 Mar 13;6(1):4-9. doi: 10.1055/s-0038-1636948. eCollection 2018 Mar.
The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery. Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons. Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons. Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff.
本研究的目的是验证大鼠肩袖修复后滑囊组织间充质干细胞向愈合部位的迁移情况。使用了Fischer大鼠和绿色荧光蛋白（GFP）转基因大鼠。从GFP大鼠分离出滑囊组织并移植到Fischer大鼠的肌腱修复部位。我们在术后1周、3周和6周检查了肩袖的组织学以及修复后的肩袖中GFP阳性细胞的比例。在术后第3周和第6周观察到了细胞迁移。我们还在修复后的肩袖肌腱中发现了间充质干细胞并形成了滑囊簇模式。间充质干细胞从滑囊组织迁移并浸润到修复后的肩袖肌腱中。滑囊组织中的间充质干细胞可促进修复后的肩袖的愈合进程。
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