State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 300071, China.
Sci China Life Sci. 2018 Apr;61(4):392-399. doi: 10.1007/s11427-017-9292-7. Epub 2018 Apr 2.
The primary reason for the failure of traditional medicine in treating the disorders of the central nervous system (CNS) is the obstruction to traverse the blood-brain barrier (BBB). Due to the unique physiochemical properties of nanoparticles, they can preferably help deliver drugs passing through the BBB. Researchers have been investigating the capacity of multifunctional nanomaterials as theranostical agents. However, some of the studies have reported controversial results, which might be due to different schematic designs, including size, surface charge, and shape. This review summarizes the applications of nanoparticles to overcome the BBB or contribute to improving the diagnostic and therapeutic effects in CNS diseases.
传统医学治疗中枢神经系统（CNS）疾病失败的主要原因是其无法穿透血脑屏障（BBB）。由于纳米粒子具有独特的物理化学性质，因此它们可以更好地帮助药物穿透 BBB。研究人员一直在研究多功能纳米材料作为治疗药物的潜力。但是，一些研究报告了有争议的结果，这可能是由于不同的设计方案，包括尺寸、表面电荷和形状所致。本文综述了纳米粒子在克服 BBB 或有助于改善 CNS 疾病的诊断和治疗效果方面的应用。
