Peedicayil Jacob
Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, India.
Curr Drug Discov Technol. 2019;16(4):392-399. doi: 10.2174/1570163815666180419154633.
The rapid and major advances being made in epigenetics are impacting pharmacology, giving rise to new sub-disciplines in pharmacology, pharmacoepigenetics, the study of the epigenetic basis of variation in response to drugs; and pharmacoepigenomics, the application of pharmacoepigenetics on a genome-wide scale.
This article highlights the following aspects of pharmacoepigenetics and pharmacoepigenomics: epigenetic therapy, the role of epigenetics in pharmacokinetics, the relevance of epigenetics to adverse drug reactions, personalized medicine, drug addiction, and drug resistance, and the use of epigenetic biomarkers in drug therapy.
Epigenetics is having an increasing impact on several areas of pharmacology.
Pharmacoepigenetics and pharmacoepigenomics are new sub-disciplines in pharmacology and are likely to have an increasing impact on the use of drugs in clinical practice.
表观遗传学领域正在迅速取得重大进展，这正在影响药理学，催生了药理学中的新子学科，即药物表观遗传学，它研究药物反应变异的表观遗传基础；以及药物表观基因组学，它是药物表观遗传学在全基因组范围内的应用。
本文重点介绍了药物表观遗传学和药物表观基因组学的以下几个方面：表观遗传疗法、表观遗传学在药代动力学中的作用、表观遗传学与药物不良反应的相关性、个性化医疗、药物成瘾和耐药性，以及表观遗传生物标志物在药物治疗中的应用。
表观遗传学对药理学的多个领域的影响日益增加。
药物表观遗传学和药物表观基因组学是药理学中的新子学科，可能会对临床实践中药物的使用产生越来越大的影响。
