Song Do Kyeong, Choi Jong Han, Kim Min Seon
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Asan Institute for Life Science, University of Ulsan College of Medicine, Seoul, Korea.
Diabetes Metab J. 2018 Apr;42(2):117-127. doi: 10.4093/dmj.2018.42.2.117.
Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have been considered to be evolutionary rudiments until a few decades, but they are now considered as important signaling organelles because many receptors, channels, and signaling molecules are highly expressed in primary cilia. A potential role of primary cilia in metabolic regulation and body weight maintenance has been suspected based on rare genetic disorders termed as ciliopathy, such as Bardet-Biedl syndrome and Alström syndrome, which manifest as obesity. Recent studies have demonstrated involvement of cilia-related cellular signaling pathways in transducing metabolic information in hypothalamic neurons and in determining cellular fate during adipose tissue development. In this review, we summarize the current knowledge about cilia and cilia-associated signaling pathways in the regulation of body metabolism.
肥胖已成为全球常见的医疗保健问题。纤毛是细胞表面微小的毛发状细胞器，由基体产生并锚定。直到几十年前，不动的初级纤毛还被认为是进化的残余物，但现在它们被视为重要的信号细胞器，因为许多受体、通道和信号分子在初级纤毛中高度表达。基于罕见的遗传性疾病，如表现为肥胖的巴德-比德尔综合征和阿尔斯特伦综合征，人们怀疑初级纤毛在代谢调节和体重维持中具有潜在作用。最近的研究表明，纤毛相关的细胞信号通路参与了下丘脑神经元中代谢信息的转导以及脂肪组织发育过程中细胞命运的决定。在这篇综述中，我们总结了目前关于纤毛和纤毛相关信号通路在身体代谢调节方面的知识。
