Department of Chemistry , University of Science and Technology of China , Hefei 230026 , China.
Org Lett. 2018 May 4;20(9):2792-2795. doi: 10.1021/acs.orglett.8b01101. Epub 2018 Apr 20.
The first catalytic enantioselective decarboxylative propargylation/hydroamination reaction of ethynyl benzoxazinanones with malononitriles enabled by organo/copper cooperative catalysis was established. Various 3-indolin-malononitrile derivatives, displaying a high tolerance for functional groups, could be obtained in good yields with high levels of enantioselectivity (up to 85% yield, 96:4 er). More importantly, this organo/metal cooperative catalytic system will provide a powerful synthetic strategy for new reaction development.
有机/铜协同催化实现了首例炔基苯并噁嗪酮与丙二腈的对映选择性脱羧炔丙基化/氨化反应。各种 3-吲哚基丙二腈衍生物在官能团容忍性方面表现出较高的反应活性，以较高的对映选择性（高达 85%的产率，96:4 的对映选择性）获得了良好的产率。更重要的是，该有机/金属协同催化体系将为新反应的开发提供一种强有力的合成策略。
