Wang Zhi-Wei, Li Yun, Liu Da-Hui, Mu Yan, Dong Hong-Jing, Zhou Hong-Lei, Guo Lan-Ping, Wang Xiao
a Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , People's Republic of China.
b College of Pharmacy , Shandong University of Traditional Chinese Medicine , Jinan , People's Republic of China.
Nat Prod Res. 2019 Apr;33(8):1140-1146. doi: 10.1080/14786419.2018.1460836. Epub 2018 Apr 20.
Four new gastrodin derivatives containing a trans-cinnamoyl unit (1-4) and nine known compounds (5-13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC values of 10.5 and 10.2 μM, respectively.
从天麻的根茎中分离出四种含有反式肉桂酰基单元的新天麻素衍生物（1-4）和九种已知化合物（5-13）。对所有这些化合物进行了针对6-羟基多巴胺诱导的细胞死亡的神经保护作用评估，化合物7和12表现出强效活性，其EC值分别为10.5和10.2 μM。
