Yang Yan, Hai Yonglin, Yang Yongcheng, Wen Rouyuan, Wang Le, Qian Yan, Zhang Jiaxian, Li Yongguo, Shi Zhilong, Zhang Haizhu
College of Pharmacy, Dali University, Dali 671000, China.
Yunnan Western Yunnan Medicinal and Edible Plant Resources Development Engineering Research Center, Dali 671000, China.
Molecules. 2025 Jan 10;30(2):262. doi: 10.3390/molecules30020262.
Blume is a well-known medicinal and edible plant in China, celebrated for its extensive history in traditional medicine and functional food applications. Among its key bioactive components, polysaccharides have drawn significant attention from researchers in the fields of health food and medicine due to their potential health benefits. Recent studies have revealed various biological activities associated with polysaccharides, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, anti-aging, immune regulation, and neuroprotective properties. However, a comprehensive overview of these polysaccharides remains elusive. Specifically, relationship between the structure and activity of polysaccharides, along with the mechanisms through which various types exert their biological effects, has yet to be fully elucidated. This knowledge gap may impede the further development and utilization of polysaccharides in medicine, health products, food, and cosmetics. This paper provides a comprehensive overview of recent advancements in extraction, separation, purification, biological activities, and applications of polysaccharides. Additionally, it delves into structure-activity relationships and pharmacological mechanisms of these polysaccharides, giving support for future research to enhance their application in medicine, food, health products, and cosmetics.
罗布麻是中国一种著名的药食两用植物，因其在传统医学和功能性食品应用方面的悠久历史而闻名。在其关键生物活性成分中，多糖因其潜在的健康益处而受到保健食品和医学领域研究人员的广泛关注。最近的研究揭示了多糖具有多种生物活性，包括抗氧化、抗肿瘤、抗炎、抗菌、抗衰老、免疫调节和神经保护特性。然而，对这些多糖的全面概述仍然难以捉摸。具体而言，多糖的结构与活性之间的关系，以及各种类型多糖发挥其生物学效应的机制，尚未完全阐明。这一知识空白可能会阻碍多糖在医药、保健品、食品和化妆品中的进一步开发和利用。本文全面概述了多糖在提取、分离、纯化、生物活性和应用方面的最新进展。此外，还深入探讨了这些多糖的构效关系和药理机制，为未来加强其在医药、食品、保健品和化妆品中的应用研究提供支持。
