S 标记定位：将 N-乙酰半胱氨酸的抗氧化活性与 HS 和硫磺酸硫物种联系起来。
S Marks the Spot: Linking the Antioxidant Activity of N-Acetyl Cysteine to HS and Sulfane Sulfur Species.
机构信息
Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA; Materials Science Institute, University of Oregon, Eugene, OR 97403, USA.
Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA; Materials Science Institute, University of Oregon, Eugene, OR 97403, USA.
出版信息
Cell Chem Biol. 2018 Apr 19;25(4):353-355. doi: 10.1016/j.chembiol.2018.04.001.
N-Acetyl cysteine (NAC) is commonly used as an antioxidant and cytoprotectant, yet a broadly applicable mechanism of these activities has remained elusive. In this issue of Cell Chemical Biology, Ezeriņa et al. (2018) report an alternative mechanism for NAC cytoprotection and antioxidant activity by demonstrating that NAC treatment increases sulfane sulfur production via intermediate HS generation.
N-乙酰半胱氨酸 (NAC) 通常被用作抗氧化剂和细胞保护剂，但这些活性的广泛适用机制一直难以捉摸。在本期《细胞化学生物学》中，Ezeriņa 等人（2018 年）通过证明 NAC 处理通过中间 HS 的生成增加了硫磺酸的产生，报道了 NAC 细胞保护和抗氧化活性的另一种机制。
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