Henan Provincial People's Hospital, 7 Weiwu Road, Zhengzhou, Henan, 450003 China; University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0021 United States.
University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0021 United States.
Biomed Pharmacother. 2018 Jul;103:473-481. doi: 10.1016/j.biopha.2018.03.121. Epub 2018 Apr 24.
Sulforaphane (SF) exhibits an anti-tumor effect in a variety of cancers, but little is known about its function in nasopharyngeal carcinoma. SF could decrease the expression of stem cell markers, β-catenin, Nanog, c-Myc, Oct3/4 and Sox2 in nasopharyngeal cancer cells (HONE1 and SUN1), and inhibit the formation of tumor spheres. Moreover, SF inhibits proliferation and induces apoptosis decreasing the stemness of nasopharyngeal cancer cells through a mechanism related to STAT3 signaling in vitro. We found that SF inhibits total STAT3 expression level and STAT3 phosphorylation (troy 704 and troy 705) by upregulation of miRNA-124-3p. Our results provide the evidence for discovering the novel drugs against nasopharyngeal carcinoma, and potential drugs targeting STAT3 signaling pathway.
萝卜硫素（SF）在多种癌症中表现出抗肿瘤作用，但关于其在鼻咽癌中的作用知之甚少。SF 可降低鼻咽癌细胞（HONE1 和 SUN1）中干细胞标志物β-连环蛋白、Nanog、c-Myc、Oct3/4 和 Sox2 的表达，并抑制肿瘤球的形成。此外，SF 通过与体外 STAT3 信号通路相关的机制抑制增殖并诱导凋亡，从而降低鼻咽癌细胞的干性。我们发现 SF 通过上调 miRNA-124-3p 抑制总 STAT3 表达水平和 STAT3 磷酸化（troy 704 和 troy 705）。我们的结果为发现新型鼻咽癌药物提供了证据，并为 STAT3 信号通路的潜在药物靶点提供了证据。
