心房利钠肽对人抗利尿激素V2受体效应的拮抗作用。
Antagonism of V2-receptor effect of antidiuretic hormone by atrial natriuretic peptide in man.
作者信息
Brown J, Forsling M L, Valdes G, Slater J D, Dollery C T
机构信息
Royal Postgraduate Medical School, London, England.
出版信息
Experientia. 1988 Jun 15;44(6):513-6. doi: 10.1007/BF01958933.
PMID:2967773
Abstract
Human alpha-atrial natriuretic peptide (h-alpha ANP) makes the urine of dehydrated volunteers hypotonic to plasma despite high circulating concentrations of antidiuretic hormone. Urinary dilution with h-alpha ANP also occurs in subjects receiving indomethacin. Therefore, h-alpha ANP antagonises effects of antidiuretic hormone on distal tubular V2-receptors in man, probably without involving prostaglandins.
摘要
人α-心房利钠肽（h-αANP）可使脱水志愿者的尿液相对于血浆呈低渗性，尽管抗利尿激素的循环浓度很高。在接受吲哚美辛治疗的受试者中，h-αANP也会导致尿液稀释。因此，h-αANP可拮抗抗利尿激素对人远曲小管V2受体的作用，这可能与前列腺素无关。
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