Kurosawa T, Sakamoto H, Katoh Y, Marumo F
Department of Medicine, Kitasato University School of Medicine, Kanagawa, Japan.
Eur J Appl Physiol Occup Physiol. 1988;57(1):10-4. doi: 10.1007/BF00691231.
To determine if the atrial natriuretic peptide (ANP) is an important factor for inducing diuresis during head-out water immersion even in dehydrated subjects, six healthy volunteers were immersed up to the neck in water at 34.5 degrees C for three hrs. Significant diuresis and natriuresis occurred, but urine osmolality decreased and negative CH2O was restored in a positive direction toward zero, even though subjects were still in a state of considerable dehydration. Plasma renin activity and plasma angiotensin I and II concentrations decreased but that of plasma aldosterone remained unchanged during water immersion, and plasma ANP did not increase throughout the examination. On the basis of the data of the present study, the factor inducing diuresis during head-out water immersion in hydrated subjects appears to differ from that in dehydrated subjects, and the main factor inducing diuresis during water immersion in dehydrated subjects may be the suppression of vasopressin release and not ANP.
为了确定即使在脱水受试者中，心房利钠肽（ANP）是否是头低位浸浴期间诱导利尿的重要因素，六名健康志愿者在34.5摄氏度的水中浸浴至颈部，持续三小时。尽管受试者仍处于相当程度的脱水状态，但仍出现了显著的利尿和利钠现象，同时尿渗透压降低，自由水清除率（CH2O）朝着正向恢复至零。浸浴期间，血浆肾素活性以及血浆血管紧张素I和II浓度降低，但血浆醛固酮浓度保持不变，并且在整个检查过程中血浆ANP并未增加。基于本研究的数据，水合受试者头低位浸浴期间诱导利尿的因素似乎与脱水受试者不同，脱水受试者浸浴期间诱导利尿的主要因素可能是血管升压素释放的抑制，而非ANP。
