Schuler T M, Frosch P J
Universitäts-Hautklinik Heidelberg.
Hautarzt. 1988 Mar;39(3):139-42.
Six patients with contact dermatitis to propolis are reported (3 women, 3 men; mean age 57 years). All three men had eczema on their hands and had acquired their sensitization in the course of bee keeping. The women had been sensitized by propolis contained in ointments of various kinds. Upon patch testing all six patients reacted to propolis and four also to Peruvian balsam. While ten flavonoids were test-negative, a cinnamic acid ester (1.1-dimethylallyl-3',4'-dihydroxy cinnamic acid ester) isolated both from propolis and from poplar buds was positive in two out of three patients; this may be the major allergen.
报告了6例对蜂胶产生接触性皮炎的患者（3名女性，3名男性；平均年龄57岁）。所有3名男性手部患有湿疹，且在养蜂过程中致敏。这些女性则因各类软膏中含有的蜂胶而致敏。斑贴试验时，所有6例患者对蜂胶有反应，4例对秘鲁香脂也有反应。虽然10种黄酮类化合物检测为阴性，但从蜂胶和杨树芽中分离出的一种肉桂酸酯（1,1 - 二甲基烯丙基 - 3',4'-二羟基肉桂酸酯）在3例患者中有2例呈阳性；这可能是主要过敏原。
