Hausen B M, Wollenweber E
Department of Dermatology, University Hospital, Hamburg, West Germany.
Contact Dermatitis. 1988 Oct;19(4):296-303. doi: 10.1111/j.1600-0536.1988.tb02931.x.
87% of the propolis product "LB-1", originally reported to be 1,1-dimethyl-allyl caffeic acid ester, was shown by GC/MS analysis to consist of 3 isomeric pentenyl caffeates, 63% of which are 1,1-dimethylallyl caffeate. These pentenyl caffeates proved to be the major sensitizers of propolis and of poplar bud secretion in our previous study. In addition, 3 further minor allergens have now been investigated. Experimental sensitization indicates that phenylethyl caffeate is as strong a sensitizer as the major allergen "LB-1", while benzyl salicylate is a moderate sensitizer. Benzyl cinnamate plays only a subordinate role. At least 3 further esters of caffeic acid or cinnamic acid remain to be studied. Interestingly, relationships between propolis and balsam of Peru were found. 8 compounds are common to both materials. Thus "cross-reactions" or concomitant reactions in propolis-sensitive individuals to balsam of Peru are explainable.
蜂胶产品“LB-1”最初被报道为1,1-二甲基烯丙基咖啡酸酯，经气相色谱/质谱分析表明，其87%由3种异构戊烯基咖啡酸酯组成，其中63%是1,1-二甲基烯丙基咖啡酸酯。在我们之前的研究中，这些戊烯基咖啡酸酯被证明是蜂胶和杨树芽分泌物的主要致敏原。此外，现已对另外3种次要过敏原进行了研究。实验性致敏表明，咖啡酸苯乙酯作为致敏原的强度与主要过敏原“LB-1”相当，而水杨酸苄酯是一种中度致敏原。肉桂酸苄酯仅起次要作用。至少还有3种咖啡酸或肉桂酸的酯有待研究。有趣的是，发现了蜂胶与秘鲁香脂之间的关系。两种物质共有8种化合物。因此，对秘鲁香脂敏感的个体在接触蜂胶时出现的“交叉反应”或伴随反应是可以解释的。
