Okun D B, Groncy P K, Sieger L, Tanaka K R
Med Pediatr Oncol. 1979;7(4):315-9. doi: 10.1002/mpo.2950070405.
An 18-year-old primagravida received combination chemotherapy with vincristine, prednisone, L-asparaginase, cyclophosphamide, daunomycin, 6-mercaptopurine and central nervous system (CNS) prophylaxis with intrathecal methotrexate and whole-brain irradiation for acute lymphoblastic leukemia (ALL) beginning in the 12th week of pregnancy. Therapy resulted in sustained complete remission of the leukemia and delivery of a normally developed female infant whose immediate neonatal course was complicated by transient severe bone marrow hypoplasia. Our experience confirms the reports of others that intensive chemotherapy can be administered in the last two trimesters of pregnancy without serious teratogenic complications. However, we conclude that such therapy may cause significant myelosuppression in the newborn.
一名18岁初产妇，在妊娠12周时开始接受联合化疗，药物包括长春新碱、泼尼松、L-天冬酰胺酶、环磷酰胺、柔红霉素、6-巯基嘌呤，并接受鞘内注射甲氨蝶呤和全脑照射进行中枢神经系统（CNS）预防，以治疗急性淋巴细胞白血病（ALL）。治疗使白血病持续完全缓解，并分娩出一名发育正常的女婴，其新生儿期即刻出现短暂的严重骨髓发育不全并发症。我们的经验证实了其他人的报道，即妊娠最后两个孕期可进行强化化疗，而无严重致畸并发症。然而，我们得出结论，这种治疗可能会导致新生儿出现显著的骨髓抑制。
