在患有糖尿病的非裔美国人中，血糖水平的变化先于痴呆，但在白种人则不然。
Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians.
机构信息
Indiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
Alzheimers Dement. 2018 Dec;14(12):1572-1579. doi: 10.1016/j.jalz.2018.03.008. Epub 2018 Apr 18.
INTRODUCTION
Changes in glucose levels may represent a powerful metabolic indicator of dementia in African-Americans with diabetes. It is unclear whether these changes also occur in Caucasians.
METHODS
A secondary data analysis using electronic medical records from 5228 African-Americans and Caucasians aged ≥65 years was carried out. Mixed effects models with repeated serum glucose measurements were used to compare changes in glucose levels between African-Americans and Caucasian patients with and without incident dementia.
RESULTS
African-Americans and Caucasians with diabetes had significantly different changes in glucose levels by dementia status (P < .0001). African-Americans experienced a significant decline in glucose levels before the dementia diagnosis (estimated glucose decline 1.3421 mg/dL per year, P < .0001) than those who did not develop dementia. Caucasians with and without dementia showed stable glucose levels over time (P = .3071).
DISCUSSION
Significant changes in glucose levels precede dementia in African-American patients with diabetes but not in Caucasians.
简介
葡萄糖水平的变化可能是糖尿病非裔美国人痴呆的有力代谢指标。目前尚不清楚这些变化是否也会发生在白种人身上。
方法
对 5228 名年龄≥65 岁的非裔美国人和白种人的电子病历进行了二次数据分析。使用混合效应模型对有和无痴呆事件的非裔美国人和白种糖尿病患者的血糖水平变化进行了重复血清葡萄糖测量的比较。
结果
按痴呆状态，非裔美国人和白种人糖尿病患者的血糖水平变化有显著差异（P<0.0001）。与未发生痴呆的患者相比，非裔美国人在痴呆诊断前血糖水平显著下降（估计每年葡萄糖下降 1.3421mg/dL，P<0.0001）。有和无痴呆的白种人血糖水平随时间稳定（P=0.3071）。
讨论
在患有糖尿病的非裔美国患者中，葡萄糖水平的显著变化先于痴呆，但在白种人中并非如此。
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