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身材矮小和受教育程度低会增加尼日利亚2型糖尿病女性患痴呆症的风险。

Short height and poor education increase the risk of dementia in Nigerian type 2 diabetic women.

作者信息

Oghagbon Efosa Kenneth, Giménez-Llort Lydia

机构信息

Faculty of Basic & Allied Medical Sciences, Department of Chemical Pathology, College of Health Sciences, Benue State University, Makurdi, Nigeria.

Department of Chemical Pathology, Benue State University Teaching Hospital, Makurdi, Nigeria.

出版信息

Alzheimers Dement (Amst). 2019 Jul 9;11:493-499. doi: 10.1016/j.dadm.2019.05.006. eCollection 2019 Dec.

Abstract

INTRODUCTION

There is urgent need to investigate type 2 diabetes and dementia crosstalk in sub-Saharan African countries with special attention to women who have higher vulnerability. Nigeria which has the highest number of diabetics on the African continent is a good location for the investigation.

METHODS

Biophysical parameters, occupation, education, burden of diabetes mellitus, cardiovascular health, and cognition were evaluated in 102 type 2 diabetics and 99 controls.

RESULTS

Short physical stature and lower level of education were hallmarks of diabetes in females. Two dementia scales (Mini-Mental State Examination and six-item Cognitive Impairment Test) showed cognitive impairment status, with the six-item Cognitive Impairment Test scale being more specific and sensitive. Both scales showed correlations with age, education, weight, height, and disease onset, whereas fasten blood glucose was negatively correlated with height and their blood pressure was normal.

DISCUSSION

Height, an easy-to-measure parameter in Nigeria, may reveal increased risk of dementia in poorly educated female Nigerian diabetics, thus helping to improve preventive and therapeutic interventions.

摘要

引言

在撒哈拉以南非洲国家,迫切需要研究2型糖尿病与痴呆症之间的相互关系,尤其要关注更易患病的女性群体。尼日利亚是非洲大陆糖尿病患者人数最多的国家,是进行此项研究的理想地点。

方法

对102名2型糖尿病患者和99名对照者的生物物理参数、职业、教育程度、糖尿病负担、心血管健康状况及认知能力进行了评估。

结果

身材矮小和教育程度较低是女性糖尿病患者的特征。两种痴呆量表(简易精神状态检查表和六项认知障碍测试)显示了认知障碍状况,六项认知障碍测试量表更具特异性和敏感性。两种量表均与年龄、教育程度、体重、身高及疾病发病情况相关,而空腹血糖与身高呈负相关,且他们的血压正常。

讨论

身高是尼日利亚一个易于测量的参数,可能揭示受教育程度低的尼日利亚女性糖尿病患者患痴呆症的风险增加,从而有助于改进预防和治疗干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df4/6624244/8c0b6136276e/gr1.jpg

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