Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA.
Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA; Center for Alzheimer's and Neurodegenerative Disease Research (CANDR), University of North Texas Health Science Center, Fort Worth, TX, USA.
Mitochondrion. 2018 Nov;43:16-24. doi: 10.1016/j.mito.2018.04.004. Epub 2018 Apr 18.
Type 2 diabetes is a significant risk factor for developing Alzheimer's disease later in life, and particular populations have a disproportionate risk because of the high prevalence of type 2 diabetes. There are many overlapping pathologies, and teasing out the primary root cause, if one indeed exists, is very difficult. Here, we review (1) the key facets of mitochondrial biology that are relevant to the two conditions, and (2) the role that mitochondrial dysfunction plays in the shared pathophysiology. We posit that mitochondrial dysfunction lies at the root of the affected processes rather than alongside them as a co-pathology.
2 型糖尿病是晚年发生阿尔茨海默病的重要危险因素，由于 2 型糖尿病的高发，某些特定人群的发病风险不成比例。这两种疾病存在许多重叠的病理，要理清（1）与这两种疾病相关的线粒体生物学的关键方面，以及（2）线粒体功能障碍在共同病理生理学中的作用，非常困难。在这里，我们假设线粒体功能障碍是受影响过程的根源，而不是作为一种共病与它们并存。
