Department of Humanities in Medicine, Pomeranian Medical University, Szczecin, Poland.
Voivodship Hospital in Szczecin Poland, Szczecin, Poland.
Adv Exp Med Biol. 2018;1114:31-39. doi: 10.1007/5584_2018_203.
Chronic respiratory diseases are determined by genetic predisposition, and environmental and socioeconomic variables. One genetic factor underlying susceptibility to such diseases can be the ABO blood group system. The purpose of this study was to investigate the hypothesis that there would be a relationship between the blood group and risk of developing asthma and chronic obstructive pulmonary disease (COPD). We reviewed medical history files of patients with the diagnosis of COPD or asthma, including those suffering from a cancerous disease accompanied by asthma or COPD, hospitalized from January 2016 to July 2017. The study involved 248 adult patients (85 women and 163 men; median age 65, range 20-95 years) with COPD (177; 71.4%) and asthma (71; 28.6%) with a known blood type. We found that the most frequent was blood type A (97; 39.1%) and the least blood type AB (26; 8.0%). The distribution of individual blood types in asthma was not different from that in COPD patients. Significant differences were found between the distribution of O and pooled non-O blood types (A, B, and AB); the pooled category was more frequent in both asthma and COPD patients. We conclude that the blood type is not a prognostic differentiating between the occurrence of asthma or COPD, although both are less common in people with blood type O. Further investigation is required to set the predisposing role of the ABO antigens for chronic respiratory diseases.
慢性呼吸系统疾病由遗传易感性、环境和社会经济变量决定。导致此类疾病的一个遗传因素可能是 ABO 血型系统。本研究旨在验证以下假设：即血型与哮喘和慢性阻塞性肺疾病（COPD）的发病风险之间存在关联。我们回顾了 2016 年 1 月至 2017 年 7 月期间因伴有哮喘或 COPD 的癌症而住院的 COPD 或哮喘患者的医疗记录。研究涉及 248 名成年患者（85 名女性和 163 名男性；中位年龄 65 岁，范围 20-95 岁），他们患有 COPD（177 例；71.4%）和哮喘（71 例；28.6%），且血型已知。我们发现最常见的血型是 A 型（97 例；39.1%），最少的是 AB 型（26 例；8.0%）。哮喘患者的各血型分布与 COPD 患者无差异。在 O 型和非 O 型（A、B 和 AB）个体血型分布之间存在显著差异；这两种血型在哮喘和 COPD 患者中更为常见。我们的结论是，血型不能作为区分哮喘或 COPD 发生的预后指标，尽管 O 型血的患者中这两种疾病的发病率较低。需要进一步的研究来确定 ABO 抗原在慢性呼吸系统疾病中的易感性作用。
