Department of Immunology and Microbiology, University of Colorado, Denver Anschutz Medical Campus, Aurora, CO 80045, USA.
Department of Medicine, Division of Biomedical Informatics and Personalized Medicine, University of Colorado, Denver Anschutz Medical Campus, Aurora, CO 80045, USA.
Curr Opin Microbiol. 2020 Aug;56:59-66. doi: 10.1016/j.mib.2020.06.008. Epub 2020 Jul 11.
The complex communities of microbes that constitute the human microbiome are influenced by host and environmental factors. Here, we address how a fundamental aspect of human biology, blood type, contributes to shaping this microscopic ecosystem. Although this question remains largely unexplored, we glean insights from decades of work describing relationships between pathogens and blood type. The bacterial strategies, molecular mechanisms, and host responses that shaped those relationships may parallel those that characterize how blood type and commensals interact. Understanding these nuanced interactions will expand our capacity to analyze and manipulate the human microbiome.
构成人类微生物组的复杂微生物群落受宿主和环境因素的影响。在这里，我们探讨人类生物学的一个基本方面，即血型，如何塑造这个微观生态系统。尽管这个问题在很大程度上尚未得到探索，但我们可以从几十年来描述病原体和血型之间关系的工作中汲取一些见解。塑造这些关系的细菌策略、分子机制和宿主反应可能与血型和共生菌相互作用的特征相似。了解这些细微的相互作用将扩大我们分析和操纵人类微生物组的能力。
