Fedele L, Arcaini L, Vercellini P, Bianchi S, Candiani G B
I Clinica Ostetrica e Ginecologica L. Mangiagalli, University of Milano, Italy.
Obstet Gynecol. 1988 Jul;72(1):19-22.
Seventy-one women underwent follow-up laparoscopy for persistent infertility six to 24 months after conservative treatment of endometriosis. The disease was staged according to the revised American Fertility Society classification of 1985. The serum CA 125 concentration was also measured in each patient to evaluate its efficacy in the diagnosis of endometriosis recurrence. The patients with stages I and II endometriosis had serum CA 125 levels not significantly higher than in the patients with negative findings, whereas those with stages III and IV endometriosis presented significantly higher levels (P less than .005 and P less than .001, respectively) than the disease-free women. The sensitivity of serum CA 125 measurements in the diagnosis of endometriosis recurrence was 14.8%, the specificity was 100%, and the predictive values of normal (less than 35 U/mL) and elevated levels were 27 and 100%, respectively. In some cases, serum CA 125 measurements may be used instead of follow-up laparoscopy, or to indicate when laparoscopy should be performed or postponed.
71名女性在子宫内膜异位症保守治疗6至24个月后，因持续不孕接受了随访腹腔镜检查。疾病根据1985年修订的美国生育协会分类进行分期。还对每位患者测量了血清CA 125浓度，以评估其在诊断子宫内膜异位症复发中的功效。I期和II期子宫内膜异位症患者的血清CA 125水平不比检查结果为阴性的患者显著更高，而III期和IV期子宫内膜异位症患者的血清CA 125水平比无病女性显著更高（分别为P < 0.005和P < 0.001）。血清CA 125测量在诊断子宫内膜异位症复发中的敏感性为14.8%，特异性为100%，正常（< 35 U/mL）和升高水平的预测值分别为27%和100%。在某些情况下，血清CA 125测量可用于替代随访腹腔镜检查，或指示何时应进行或推迟腹腔镜检查。
